Repression of WNT-TCF signaling with pan dominant-negative TCF (dnTCF4), shown to be effective in vitro on human colon cancer cells (e.g. [18]), is, paradoxically, generally ineffective in repressing tumor growth after grafting advanced human colon cancers; In contrast, it can boost metastatic growth after direct seeding of cancer cells in the lungs [10], [11], [19–21]. Here, HNF4A is linked to malignant colon neoplasm.