There is a large body of evidence that supports the notion that WNT signaling is critical for human colon cancers, which is perhaps best exemplified by two key findings i- the vast majority of colon cancers harbor mutations in the tumor suppressor APC, a key WNT-TCF pathway antagonist [1], and ii- restoration of Apc function in apc compromised mice results in the loss of intestinal tumors [2]. This evidence concerns the gene HNF4A and malignant colon neoplasm.