In this and other studies downregulation of TCF function has been afforded by dnTCF4 (e.g. [10], [18]) and the downregulation we report affects the growth of T84 and HT29 tumors (albeit very slightly in the latter case; this work) and similar levels are effective in repressing DLD1 colon cancer cell xenograft growth [10]. The gene discussed is HNF4A; the disease is colonic neoplasm.