GAP-43 and PSD95, the postsynaptic markers for increased synaptic activity, were increased significantly in both cortex and hippocampus of 3xTg-AD mice treated with midi-GAGR compared to control while synaptophysin (SYN) remained unchanged (Fig 11A, 11C, 11D and 11E). The gene discussed is SYP; the disease is Alzheimer disease.