We found that delivery of exogenous LFn-NADase to the cytosol of GAS-infected OKP7 cells reduced the co-localization of 188 G330D with the lysosomal marker LAMP-1 (Lysosomal–Associated Membrane Protein 1) by 4-fold, from 41% to 10% at 6 h of infection (P<0.001, Fig 6). The gene discussed is LAMP1; the disease is infection.