To test the cell-autonomous requirement for IFN signalling in the up-regulation of EVL and pri/pre-miR-342 during infection, we analysed by microarray the endogenous regulation of these transcripts in BMDM with a genetic ablation in IFN beta (IFN-β), the type 1 IFN receptor (IFNAR1 –UniProt: P17181) (Fig 6E) or the down-stream signalling molecule tyrosine kinase 2 (TYK2 UniProt: Q9R117) (S4D and S4E Fig). This evidence concerns the gene TYK2 and infection.