We did not observe any statistically significant association between the 22 SNPs or MC1R with the FAMMM syndrome, allthough that we prior to Bonferoni correction observed statistically significant associations with the vitamin D receptor (VDR) SNP rs1544410 G and the agouti signalling protein (ASIP) SNP rs1015362 G (non-corrected p = 0.007 (0.33 corrected) and p = 0.009 (0.43 corrected), respectively). This evidence concerns the gene VDR and familial atypical multiple mole melanoma syndrome.