Recent analysis of genome wide occupancy of ETS factors ERG and FLI-1 in AML-ETO positive SKNO-1 human AML cells has revealed that both factors occupy common genomic regions and that a subset of ERG/FLI-1 occupied enhancers direct the majority of AML-ETO binding for aberrant transcriptional repression of myeloid differentiation genes [36,68–70], Therefore, the enrichment of the ETS and RUNX1 motifs in the NR4A1 targetome could potentially represent antagonism of AML-ETO by NR4A1. Here, ERG is linked to acute myeloid leukemia.