Null mutation of both NR4A1 and NR4A3 results in a cell-autonomous and transplantable acute myeloid leukemia (AML)-like disease characterized by proliferative expansion of hematopoietic stem cells and accumulation of undifferentiated myeloid blasts in non-hematopoietic tissues [11]. This evidence concerns the gene NR4A3 and acute myeloid leukemia.