Our observation that NR4A1-dependent histone acetylation requires expression of the ETS factors ERG/FLI-1 and is associated with NR4A1-dependent recruitment of FLI-1 to the NR4A1 distal primed enhancers at a subset of induced NR4A1 target genes suggests that NR4As may be capable of reprogramming ERG/FLI-1 binding in AML, though this remains to be tested on a global scale. Here, NR4A1 is linked to acute myeloid leukemia.