Null mutation of both NR4A1 and NR4A3 results in a cell-autonomous and transplantable acute myeloid leukemia (AML)-like disease characterized by proliferative expansion of hematopoietic stem cells and accumulation of undifferentiated myeloid blasts in non-hematopoietic tissues [11]. Here, NR4A1 is linked to acute myeloid leukemia.