Interestingly, analysis of the ERG cistrome in human CD34+ hematopoietic progenitors previously identified the nuclear receptor half site as a coenriched motif with ERG binding sites [36], suggesting that nuclear receptors may cooperate with ERG in non-AML hematopoietic progenitor populations, and we and others have previously shown that NR4As are highly expressed within this population [10,11]. The gene discussed is CD34; the disease is acute myeloid leukemia.