Within this complex scenario, our data reveal that the NK-cell response triggered by CHIKV/DENV-2 co-infection reflects a combination of the results observed in mono-infected patients, in terms of potency and durability (ie NKp30, NKG2A and CD161), and a unique profile of KIR2DL2/2DL3 and KIR2DL1 co-expression. Here, NCR3 is linked to coinfection.