Moreover, it may well be that a subtype of PD / DLB exists that is particularly influenced by these anti-inflammatory species and neurotrophic factors: We found that PD patients with a LRRK2 mutation who displayed a diffuse-malignant phenotype [44], showed higher levels compared to PD LRRK2 patients with the much more benign pure motor phenotype [45]. This evidence concerns the gene LRRK2 and Parkinson disease.