The expression levels of claudin1, occludin and zonula occludens-1 (ZO-1) proteins in rats of the HF group were significantly lower than those in the Chow group (claudin1, 0.55 ± 0.18 vs. 1.00 ± 0.22, p < 0.01; occludin, 0.36 ± 0.11 vs. 1.00 ± 0.23, p < 0.01; ZO-1, 0.24 ± 0.15 vs. 1.00 ± 0.40, p < 0.05). Here, OCLN is linked to hydrops fetalis.