LPS-activated macrophages secrete a considerable number of inflammatory mediators, such as nitric oxide (NO), interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor (TNF)-α, and prostaglandin E2 (PGE2), all of which contribute to host survival following infection and are required for the innate immune response of many mammals [2,3]. This evidence concerns the gene TNF and infection.