EIF2AK3 and dengue disease: p62 is degraded as a result of high rate of degradation of autophagosome content in the lysosomes, the final step of autophagy.39 We used PERK+/+ (wild type) and PERK−/− (knockout (KO) variants) mouse embryonic fibroblast (MEF) cells to examine the effect of PERK on dengue-induced autophagy (Figure 2a).