AKT1 and cancer: To elucidate the possible mechanism by which MALAT1 regulates the proliferation and invasion of glioma cell, western blot analysis of the key molecular factors of cancer-related pathways, such as nuclear factor kappaB, mTOR, Akt and others (data not shown), was performed.28, 29, 30 The ERK/MAPK pathway is one of the most important signal transduction pathways, and upregulation of MALAT1 inhibits the growth and invasion of tumor by inactivating this signaling cascade.