To elucidate the possible mechanism by which MALAT1 regulates the proliferation and invasion of glioma cell, western blot analysis of the key molecular factors of cancer-related pathways, such as nuclear factor kappaB, mTOR, Akt and others (data not shown), was performed.28, 29, 30 The ERK/MAPK pathway is one of the most important signal transduction pathways, and upregulation of MALAT1 inhibits the growth and invasion of tumor by inactivating this signaling cascade. This evidence concerns the gene AKT1 and neoplasm.