Hence it was hypothesized that MALAT1 could probably inactivate the ERK/MAPK pathway via regulation of the expression of GPC6 or CXCL5 genes in glioma, which requires further study Overall data suggest tumor-suppressive effect of MALAT1 in glioma, by inhibiting the proliferation and invasion of glioma, and inactivates via regulation of the ERK/MAPK pathway and expression of MMP2. Here, GPC6 is linked to central nervous system cancer.