GPC6 and lung cancer: In previous studies, it has been proved that knockout of MALAT1 in lung cancer cells could significantly reduce the expression of several metastasis-related genes including Glypican 6 (GPC6) and C-X-C motif chemokine 5 (CXCL5),35, 36 while depletion of GPC6 or CXCL5 could lead to the inactivation of the MAPK pathway.