A recent study showed that NF-κB is responsible for inflammatory mediators and survival proteins; moreover, certain pathogens modulate apoptosis by interfering with NF-κB expression.43 In this study, cleaved caspase-3 was activated when cells were treated with CQ and BAY11-7082 in MM+LPS; however, cleaved caspase-3 expression decreased sharply with rapamycin treatment. The gene discussed is NFKB1; the disease is Miyoshi myopathy.