For example, Runx1 binds and activates the +37 kb Cebpa enhancer [7], and ChIP-Seq demonstrated that the RUNX1-ETO AML oncoprotein binds specifically at the +42 kb CEBPA enhancer, but not the CEBPA promoter, in two patient samples and in the Kasumi-1 cell line [51], likely leading to Cebpa trans-repression. This evidence concerns the gene CEBPA and acute myeloid leukemia.