GSTM1 plays critical role in liver diseases as supported by our gene-gene interaction data where cumulative effect of this null variant has been observed with GSTT1 null genotype, rs4880 of MnSOD and rs2066701 of ADH1B. Again, Alanine to Valine change in the 9th position of mitochondrial target sequence of the single mitochondrial superoxide scavanger MnSOD which alters its amphiphilic helical structure crucial for transport and processing of mitochondrial protein varies among ethnic groups. This evidence concerns the gene ADH1B and liver disorder.