These two loci are in complete LD (D’ = 1.0) (data not shown) and the related haplotype CYP2E1*5B is associated with higher transcription of CYP2E1. Significant association of this variant with ALD and other liver diseases has been documented in Oriental [32] and North Indian population [33] but not in Caucasians [34]. This evidence concerns the gene CYP2E1 and liver disorder.