The aims of this study were to assess whether resected CRLM could be classified into morphological types, based not only on the morphology of the tumor-liver parenchymal interface but also on the morphology of the glands and vascular pattern of the metastases; whether these morphological types of CRLM have a prognostic significance; and whether the morphology may be associated with different levels of expression of hypoxic factors (HIF-1α and CA-9) and VEGF, which influence tumor angiogenesis and tumor proliferation. The gene discussed is VEGFA; the disease is neoplasm.