It is contrary to studies assessing the relationship between VEGF and MVD in primary CRC as well as a single study of CRLM in which high expression of VEGF was associated with an increased MVD.34 However, Nakamoto et al35 who studied the expression of angiogenic factors in primary CRC and CRLM reported a positive correlation between VEGF and MVD in primary CRC but did not find a correlation between VEGF and MVD in liver metastases. Here, VEGFA is linked to colorectal carcinoma.