PIK3CA and neoplasm: Human homolog of KIF2A is a motor protein engaged in transporting cargo proteins along microtubules, which specifically localizes to centrosomes during mitosis.6 It was reported that KIF2A silencing induced tumor cell apoptosis in vitro partially by suppressing the PI3K/AKT signaling pathway,7 a pathway commonly overactivated in a wide spectrum of human cancers.