PIK3CA and ovarian cancer: Another important protein-related PI3K/AKT pathway is human epidermal growth factor receptor 2 (HER2-neu, alias: ERBB2), which is implicated in carcinogenesis of various cancer types, including ovarian cancer.8 HER2-neu is a tyrosine kinase receptor in the epidermal growth factor family and plays an important role in cell proliferation and tumor cell metastasis.