JUP encodes a cytoplasmic protein that belongs to the catenin family whose members actively interact with APC. 28BLMH encodes a cytoplasmic cysteine peptidase that metabolically inactivates the glycopeptide bleomycin, an essential component of combination chemotherapy regimens for cancer.29 Our results suggest that this gene could be synthetic lethal to KRAS and is a potential therapeutic target for KRAS mutant cancers. This evidence concerns the gene APC and cancer.