TACC3 and cancer: This result indicates that TP53 mutant cancer cells could rely on the high expression of TACC3 or MYC for survival, predicting the synthetic lethality relationship between TACC3 and TP53, and between MYC and TP53. The other highly expressed genes in TP53 mutant BRCAs include CDK6 and CCT6A which are likely to be synthetic lethal to TP53 (Table 5).