TDO2 and cancer: TDO2 encodes a protein that may play a role in cancer through the suppression of antitumor immune responses.35 Thus, the associations of APC, TDO2 and antitumor immune responses are worthy to be further investigated since cancer immunotherapy could be a fundamental breakthrough in cancer treatment.36CDK6 has significant lower GPVs in the TP53 mutant cell lines than in wide-type cell lines (P value <10–4), and significantly higher level of expression in TP53 mutant cancer cell lines than in wide-type cell lines (P value <10–7, fold-change = 1.56).