IL1B and Alzheimer disease: As shown in Table 3, AD patients carrying the IL-1β TT genotype at the -31 site had the lowest MMSE score (18.6 ± 5.7), highest ESS score (9.4 ± 6.6), longest REM latency (168.2 ± 33.0 min), and lowest percentages of REM (16.6 ± 5.3%) and SWS (0.2 ± 0.2%) among the three IL-1β-31 genotypes; in contrast, no significant difference was found among the IL-1β-31 genotypes in the healthy controls.