A significant genetic association between the SNPs rs7903146 (odds ratio 1.69, 95 % confidence interval 1.21–2.38, P = 0.002) and rs12255372 (odds ratio 1.70, 95 % confidence interval 1.20–2.41, P = 0.003) at TCF7L2 and T2D was found in Sudanese population. Here, TCF7L2 is linked to type 2 diabetes mellitus.