CYP2D6 and movement disorder: The sampled cohort was selected for having marked risperidone-related ADRs (risperidone induced movement disorders and weight gain), Although the significance of CYP2D6 polymorphisms affecting risperidone metabolism in both drug naïve and experienced patients has been well established (Jovanovic et al., 2010), it is still unclear whether genetic mutations in CYP2D6 are associated with ADRs.