Considering the percentage in CLL2007-SA, the median of total CD20 splicing (1.26 ± 1.23 %) was significantly higher than in routine CLL (0.65 ± 0.5 %, p < 0.02) or BOMP (0.76 ± 1.02 %, p < 0.001) (Figs. 7a, 8). Here, MS4A1 is linked to B-cell chronic lymphocytic leukemia.