In oncohematology, numerous spliceosome gene mutations have been identified in chronic lymphocytic leukemia (CLL), myelodysplastic syndromes, and lymphomas; among the most well-known of these are those involving SF3B1, U2AF1, and SRSF2 [18–20]. The gene discussed is SRSF2; the disease is B-cell chronic lymphocytic leukemia.