Treatment of the CML cell lines LAMA-84 and K562 with therapeutic IM doses for 24 h revealed decreased expression levels for c-MYB and ESPL1/Separase on both transcriptional and protein levels as shown on representative Western blot composite images (Fig. 1, Table 1). This evidence concerns the gene ESPL1 and chronic myelogenous leukemia, BCR-ABL1 positive.