ABL1 and leukemia: In accordance with data from extensive studies on the dose-dependent effects and time kinetics of IM we applied lower IM doses (range: 1 to 2.5 μM) for leukemia-derived p210BCR-ABL-positive cells (LAMA-84 and K562) than for p210BCR-ABL-negative cells (U937, 5 μM) [53, 54].