ANGPT2 and asthma: When asthmatics were stratified according to the severity, the mean serum level of Angiopoietin-2 was found to be significantly higher in patients with SRA as compared to nSA (6.04 ± 0.46 vs 3.84 ± 0.43; p < 0001), and in both asthma groups mean Angiopoietin-2 levels were higher as compared to HC (Fig. 1a).