To further explore the relationship between FGFR1 signaling and cancer stem cell traits, we measured the mRNA levels of stem cells markers CD133 [8], NANOG [6], OCT4 [6] and SOX2 [5], when FGFR1 signals were activated by bFGF, and in the presence of FGFR1 inhibitor. The gene discussed is SOX2; the disease is cancer.