Classification of the early-onset Alzheimer’s disease group in comparison with the FTLD groups, based on the PA scale, was similar to previous reports in the literature [AUC = 0.63 (Tau), AUC = 0.67 (TDP-43) versus AUC = 0.66 (mixed FTLD) (Lehmannet al., 2012)]. This evidence concerns the gene TARDBP and early-onset autosomal dominant Alzheimer disease.