Unlike HSP70, DNAJB2a expression is specifically enriched in neuronal tissues (Chapple and Cheetham, 2003;Hageman and Kampinga, 2009) and mutations in DNAJB2 are linked to a rare recessive distal hereditary motor neuropathy and Charcot–Marie–Tooth disease type 2 (Blumenet al., 2012;Gesset al., 2014) implying a critical need for this co-chaperone. This evidence concerns the gene HSPA1A and distal hereditary motor neuropathy.