Multiple ALS-causing mutations have been identified on theTARDBPgene coding for TDP-43, which promotes TDP-43 translocation to the cytosol, stabilizes and promotes the aggregation of the mutant protein (Johnsonet al., 2009;Barmadaet al., 2010;Linget al., 2010). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.