Further, somatic mutations were identified in multiple Notch pathway genes, including those that encode Nicastrin, MAML1 and Notch2, in samples from CMML patients, demonstrating a tumor-suppressive role for Notch signaling in addition to involvement in early HSC differentiation (Klinakis et al., 2011). The gene discussed is NCSTN; the disease is chronic myelomonocytic leukemia.