RBPJ and neoplasm: In addition, RBP-J-deficient DCs exhibited attenuated expression of the antigen presenting molecules MHC II, co-stimulatory molecules CD80 and CD86 in response to tumor antigens and displayed a reduced capacity to activate T cells in relation to T cell proliferation, T cell cytokine production (IFNγ and IL-4) and cytotoxicity (Feng et al., 2010).