CSF3 and myeloproliferative disorder: Interestingly, the AD-like inflammation associated with Notch deficiency was accompanied by G-CSF-induced myeloproliferative disorder (MPD) characterized by an increase in immature myeloid populations in the bone marrow and spleen (Dumortier et al., 2010), suggesting a protective role for Notch against myeloproliferation similar to that observed by Klinakis et al. (2011).