Similar to simultaneous ablation of Notch1 and Notch2 or RBP-J (Dumortier et al., 2010), ADAM17 inactivation in the keratinocyte compartment resulted in increased epidermal TSLP expression and spontaneous onset of AD and MPD in mice (Murthy et al., 2012). The gene discussed is NOTCH1; the disease is Alzheimer disease.