Human post-mortem brain tissue from cases with early-onset FAD, CBD, PSP and control individuals without neurodegeneration was analysed by immunohistochemistry to determine the presence of hyperphosphorylated tau using two different phospho-tau antibodies: clone AT8 (pS202/T205, Fig. 1) and Tau/pS422 (Additional file 1: Figure S1). This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.