Quantification of the PLA signal (Fig. 4i) showed significantly more colocalization of hyperphosphorylated tau and LC3 in FAD (11.5 ± 2.2 dots/field), CBD (17.2 ± 5.3 dots/field) and PSP (13.9 ± 6.9 dots/field) compared to control individuals (0.7 ± 1.2 dots/field; p < 0.05 vs FAD, p < 0.01 vs CBD and p < 0.05 vs PSP). The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.