However, some myeloid-lineage cells and resting CD4+ T-cells from individuals with SAMHD1-inactivating mutations supported robust infection in vitro12, 29, suggesting that the observed anti-IFN activity of SAMHD1 is cell type specific or that its ablation is insufficient to allow the interferon response to protect against HIV-1 infection. Here, SAMHD1 is linked to HIV-1 infection.