FOXO3 and Familial prostate cancer: Both FoxO and Wnt/Wg signaling have been implicated in various cancers2, 3, 12, 13, 37, and a FOXO3a/β-catenin/GSK-3β signaling is essential for cell proliferation and apoptosis in prostate cancer cells38, further study is needed to understand their interaction in tumorigenesis.