Both FoxO and Wnt/Wg signaling have been implicated in various cancers2, 3, 12, 13, 37, and a FOXO3a/β-catenin/GSK-3β signaling is essential for cell proliferation and apoptosis in prostate cancer cells38, further study is needed to understand their interaction in tumorigenesis. This evidence concerns the gene FOXO3 and prostate cancer.