The objective of the present study is to evaluate the association of the two ABCA1 polymorphisms, rs2230806 [R219K: c.656G>A (p.Arg219Lys)] and rs2066715 [V825I: c.2473G>A (p.Val825Ile)], and two CETP polymorphisms, rs5882 [V422I: c.1264G>A (p.Val422Ile)] and rs708272 [TaqIB: c.118+279G>A], with the risk of CAD in the population of the Eastern Province of Saudi Arabia. This evidence concerns the gene CETP and coronary artery disorder.