However, Borggreve et al. in their prospective population-based study (PREVENT study) on 8141 Caucasians demonstrated that the B2 and I alleles of the rs708272 (TaqIB) and rs5882 (V422I) of the CETP gene were not associated with a decreased risk for CAD, despite their HDL-C-raising effect suggesting that the risk may be independent of the gene’s influence on HDL-C levels [44]. This evidence concerns the gene CETP and coronary artery disorder.