For instance, both inflammation and insulin resistance can cause hepatic steatosis through increasing liver expression of genes for lipogenic enzymes such as acetyl-CoA carboxylase 1 (ACC1) and fatty acid synthase (FAS) and decreasing liver expression of genes for fatty acid oxidation including carnitine palmitoyltransferase 1a (CPT1a)11, 12, 13. This evidence concerns the gene ACACA and fatty liver disease.