134 targets of 93 compounds were RA disease genes (Fig. 2a), e.g. TNFSF11 (tumor necrosis factor superfamily, member 11) and IL18 (interleukin 18), etc. To further compare the functional relationships between GSZ formula targets and RA disease genes, we investigated the biological processes of the genes involved (Fig. 2b). This evidence concerns the gene TNFSF11 and rheumatoid arthritis.