HLA-DRB1 and rheumatoid arthritis: In module 10, two formula targets (MLRW [major histocompatibility complex, class II, DR alpha] and HLA-DRB1 [major histocompatibility complex, class II, DR beta 1]) directly or indirectly interact with five disease genes (Supplement Table S8) that all belong to the HLA class II and were related to incidence, mortality, and treatment response of rheumatoid arthritis through biological process about peptides17, 47, 48.