In module 2, fibronectin 1 (FN1, also known as MSF), decorin (DCN, also known as SLRR1B) and matrix metallopeptidase 2 (MMP-2, also known as TBE-1) might be the core members of module 2 by connecting other 50 GSZ targets or RA disease genes in this module. The gene discussed is MMP2; the disease is rheumatoid arthritis.