For example, by combining microarray gene expression profiling with Connectivity Map, Si-Wu-Tang was identified as an Nrf2 (nuclear factor-erythroid 2-related factor) activator and phytoestrogen21; a multi-level integration of herbs, compounds and targets uncovered the pharmacological mechanism of Sheng-ma-bie-jia-tang formula for Systemic Lupus Erythematosus treatment22. Here, NFE2L2 is linked to systemic lupus erythematosus.