The mechanism of chemo-resistance is very complex, but the overexpression of some ATP-binding cassette (ABC) transporters and cancer stem cells, are two main causes of chemo-resistance [5–8].Interestingly, recent studies have shown that sal-like 4 (SALL4) gene, a member of the mammal homologs of Drosophila homeotic gene spalt, is shared by stem cells with tumor cells promoting their proliferation and conferring drug resistance on them. Here, SALL4 is linked to neoplasm.