BC200 was also shown to have a role in aging and Alzheimer’s disease: Mus et al. (2007) [50] have demonstrated that normal aging is associated with decreased BC200 expression in the brain, while BC200 expression was significantly upregulated in the brains of Alzheimer’s patients, where abnormal localization to the perykarial region was observed. This evidence concerns the gene BCYRN1 and early-onset autosomal dominant Alzheimer disease.