Canonically, the GDNF ligand serves as a chemoattractant to GFRA1-expressing mouse GABAergic cortical cells56, rat glioma cells57, 58 and mouse corneal epithelial cells59, and also serves neurotrophic functions in normal and diseased mammalian retina27, 60, 61. The gene discussed is GFRA1; the disease is central nervous system cancer.