TEWL was significantly higher in the FLG-null AD group than in the WT AD group (FLG-null AD: 8.7 ± 1.9 g/m2/h vs WT AD: 8.1 ± 5.6 g/m2/h, P = .02; Fig 3, A). The gene discussed is FLG; the disease is Alzheimer disease.