Oil red O staining in the xenograft tumor tissues showed that knockdown of P300 or FASN decreased the lipid accumulation in C4-2 xenografts in vivo, but double knockdown of P300 and FASN did not result in further significant inhibition of lipid accumulation in C4-2 tumors in mice (Figure 7G and 7H), consistent with the tumor growth data (Figure 7E and 7F). Here, EP300 is linked to neoplasm.