In view of these recent observations showing that altered function of CAPERα promoted tumorigenesis, we were interested in determining the frequency of anti-CAPERα autoantibody responses in HCC and other solid tumors and whether it might be possible to show the relationships existing between CAPERα and VEGF expression and whether they were associated with microvessel density in HCC. Here, VEGFA is linked to hepatocellular carcinoma.