CCND1 and acute myeloid leukemia: In addition, HNA inhibited transcriptional levels of several targeted genes of miR-34a (c-Myc, cyclin D1, CDK4) in NB4 cells (Figure 7D); Also in the AML cells, the miR-34a antagonist restored protein expression levels of c-Myc and cyclin D1 proteins, these had been inhibited in their expression in the presence of HNA alone.