Imamura et al. reported that Lgl2, the homologous protein of Lgl1 in human, was co-locaolized and interacted with the aPKC lambda/iota in cell apical membrane of lung adenocarcinoma tissues by double-immunohistochemical analysis, which raised a possibility of phosphorylation of Lgl2 by aPKC λ/ι in lung cancer [43]. This evidence concerns the gene LLGL2 and lung cancer.