Recently, the list of such examples has grown to include ATRX, BCOR, BRAF, CREBBP, CTNNB1, KDM5C, MED12, MET, PHF6, PTPN11, EP300, SMARCB1, and MLL2 [3,18–36]. Copy number variants (CNVs) also contribute to this list as several CNVs believed to underlie neurodevelopmental disorders also contain cancer predisposition genes [37]. Here, MET is linked to cancer.