Tamburrino et al. showed that the PI3K/Akt/mTOR pathway is crucial to MTC tumorigenesis [20] and in a recent review, Manfredi et al. showed that MTC cell proliferation depends on PI3K/Akt/mTOR signaling, suggesting a novel therapeutic target for MTC [21]. The gene discussed is AKT1; the disease is medullary thyroid gland carcinoma.