BAX and hepatocellular carcinoma: In vitro, diclofenac induced apoptosis through mitochondrial dysfunction and oxidative stress in rat and human hepatocytes and hepatoma cell lines [5] and Bax/Bak-mediated mitochondrial outer membrane permeabilization (MOMP) was shown to be a major mechanism of diclofenac-induced hepatotoxicity in a human hepatoma cell line [6, 7].