HDAC9 and acute myeloid leukemia: Another putative mechanism of action of HDAC inhibitors in single and combination studies is that of oxidative injury [16, 37, 39], This process is driven through NOX-mediated ROS induction which has been shown by our group to be constitutively active in myelomonocytic AML subtypes [40], and which may, in part, contribute to the greater efficacy of tefinostat in these patients.