FLT3 and acute myeloid leukemia: Although HDACis have been previously reported to selectively target FLT3 ITD-mutant proteins for degradation in AML [41] and to enhance FLT3 inhibition in cell lines [42, 43], we found no association between in vitro sensitivity to tefinostat and FLT3-ITD mutation status in our primary sample cohort (Supplementary Table S1).