F5 and atypical hemolytic-uremic syndrome: The authors then hypothesized that local degradation of FV by EspP, secreted by EHEC attached to the gastrointestinal mucosa, may result in a reduction of FV activity leading to prolongation of coagulation time; EspP may therefore play a role in the pathophysiology of D+HUS by increasing haemorrhage into the gastrointestinal tract [3].