These drugs also inhibit the expression of α‐granule‐stored proteins that are involved in heterotypic interactions between platelets/leukocytes and the endothelium including P‐selectin and CD40L.51 Reducing platelet activation alters how immune‐mediated chronic hepatitis progresses, impacting even cancer development.51 Modulating the way platelets deliver serotonin to the liver sinusoid during injury may also be open to therapeutic manipulation. This evidence concerns the gene CD40LG and chronic hepatitis.