However, when studied in the context of nonviral hepatic inflammation, for example, acute liver injury due to acetaminophen toxicity, serotonin deficiency worsens outcome,94 possibly through the ability of serotonin receptor 5HT 2A to reduce TNF‐α‐mediated inflammation.95 Serotonergic agonists may therefore be of therapeutic benefit during acute nonviral liver inflammation, but little is known about the effect of drugs such as selective serotonin reuptake inhibitors on liver inflammation or regeneration. This evidence concerns the gene TNF and inflammation.