MMP14 and neoplasm: The compound inhibited tumor cell migration on collagen and effectively repressed tumor growth in an in vivo mouse model, confirming that the dimer form of MT1-MMP was necessary for optimal cell surface function [32] Similarly, synthetic peptides mimicking the outermost strand motifs within the hemopexin domain of MT1-MMP defined as essential for homo/hetero dimerisation were shown to specifically inhibit MT1-MMP-enhanced cell migration, although the ability to directly prevent MT1-MMP proteolytic activity was not shown [33].