When NOR1 function is “off” (e.g., silenced by DNA hypermethylation during NPC progresses [24]), NOR1 protein levels decrease, which secondarily leads to dysfunction of the FOXA1-HDAC2 complex, thus relieving the inhibitory effect on the Slug-induced EMT process (Figure 8). This evidence concerns the gene HDAC2 and nasopharyngeal carcinoma.